Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox not checked   Rule 13d-1(b)
Checkbox checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)






SCHEDULE 13G




Comment for Type of Reporting Person:  Percentage reported in Item 11 is based on 32,620,177 shares of Common Stock outstanding as of March 13, 2025, (as provided by the Issuer in its Rule 424(b)(3) prospectus filed with the Securities and Exchange Commission (''SEC'') on March 28, 2025), and 1,714,284 warrants beneficially owned by the reporting persons as described in Item 4(a), with each warrant currently exercisable into one share of Common Stock.


SCHEDULE 13G




Comment for Type of Reporting Person:  Percentage reported in Item 11 is based on 32,620,177 shares of Common Stock outstanding as of March 13, 2025, (as provided by the Issuer in its Rule 424(b)(3) prospectus filed with the SEC on March 28, 2025), and 1,714,284 warrants beneficially owned by the reporting persons as described in Item 4(a), with each warrant currently exercisable into one share of Common Stock.


SCHEDULE 13G




Comment for Type of Reporting Person:  Percentage reported in Item 11 is based on 32,620,177 shares of Common Stock outstanding as of March 13, 2025, (as provided by the Issuer in its Rule 424(b)(3) prospectus filed with the SEC on March 28, 2025), and 1,714,284 warrants beneficially owned by the reporting persons as described in Item 4(a), with each warrant currently exercisable into one share of Common Stock.


SCHEDULE 13G



 
Sphera Funds Management Ltd.
 
Signature:/s/ Adi Hanetz
Name/Title:Adi Hanetz / General Counsel
Date:04/10/2025
 
Sphera Global Healthcare GP Ltd.
 
Signature:/s/ Adi Hanetz
Name/Title:Adi Hanetz / General Counsel
Date:04/10/2025
 
Sphera Global Healthcare Management LP.
 
Signature:/s/ Adi Hanetz
Name/Title:Sphera Global Healthcare Management LP.
Date:04/10/2025
Exhibit Information

Exhibit 1: Joint Filing Agreement by and among the reporting persons


Exhibit 1

Joint Filing Agreement

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of Outlook Therapeutics, Inc. (the “Issuer”); each of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate. In accordance with Rule 13d-1(k)(1), the undersigned hereby agree to the joint filing with each other on behalf of each of them of such a statement on Schedule 13G and any amendments thereto with respect to the equity securities (as defined in Rule 13d-1(i)) of the Issuer, beneficially owned by each of them. This Joint Filing Agreement shall be included as an exhibit to such Schedule 13G and any amendments thereto.

This agreement may be executed in any number of counterparts, each of which shall be deemed an original.
 
March 3, 2025

  Sphera Funds Management Ltd.
 

   

/s/ Adi Hanetz  

By: Adi Hanetz
 
  Title: General Counsel  

  Sphera Global Healthcare GP Ltd.
 

   

/s/ Adi Hanetz  

By: Adi Hanetz
 
  Title: General Counsel  

  Sphera Global Healthcare Management LP
 

   

/s/ Adi Hanetz  

By: Adi Hanetz
 
  Title: General Counsel